Clinical studies on pQCT & Leonardo
pQCT and Leonardo
Bone density measurement and force plate
Clinical studies
In clinical research, the measurement of bone mass is currently primarily used to assess changes in bone metabolism. However, the influence of bone geometry and musculature is often not taken into account. The combination of pQCT for measuring bone strength and Leonardo mechanography for determining muscular maximum forces, performance as well as fall risk enables a comprehensive objective analysis of physiological processes or therapy based on scientific principles. In this way, the control loops underlying bone adaptation (Wolff's law, "mechanostat") can be characterised and the relevant effects of a therapy can be documented.
pQCT offers more than just bone mass measurement
Spongiosa and cortical density in g/cm³, bone strength, bone geometry and muscle cross-sectional area are determined using pQCT. Unlike conventional methods, the pQCT measurement provides the results in physically correct units (g/cm³ instead of g/cm²). Cancellous bone and cortical bone can be evaluated separately. Important muscle properties such as cross-sectional area or density can also be evaluated simultaneously. The results are independent of body size and weight. Furthermore, there is no influence of extraosseous calcification and changes in soft tissue composition that are common with other measurement methods.
Muscle cross-section and muscle density
pQCT also allows quantification of muscle parameters such as muscle cross-sectional area and muscle density. On the one hand, these are crucial for bone adaptation ("mechanostat"), and on the other hand, muscle parameters are essential for defining the clinical pictures of sarcopenia and dynapenia.
Influence of the musculature on the bone - Leonardo mechanography
Bone strength is primarily controlled by maximum muscle forces. Therefore, the measurement of muscle function is indispensable for an analysis of the bone. Leonardo mechanography allows the exact measurement and analysis of important parameters of muscle function such as force, power, speed, stiffness and energy with high reproducibility. By comparison with the measurement of the muscle cross-sectional area, the efficiency of the muscle can also be analysed. Thus, a distinction can be made between muscle-related therapy effects and others.
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pQCT
The 3rd Dimension in Bone Density Assessment
XCT 2000L
Determination of
volumetric bone density,
Bone geometry and
Muscle parameters of arm or
Lower leg using pQCT.
XCT 3000
Determination of volumetric
Bone density, bone geometry
and muscle parameters of the arm or
Leg measureed by pQCT.
Leonardo Mechanography
Muscle Function & Performance Diagnostics
Leonardo Mechanograph
GRFP LT
Entry-level system for muscle functional diagnostics and performance assessment
Leonardo Mechanograp
GRFP STD + Bench
The compete package with measurement of side-differences and optional bench for chair rise tests